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A paper regarding ubiquitin-based MET agonists has been published in Angewandte Chemie

Writer's picture: Naohiro TerasakaNaohiro Terasaka

A co-authored paper at the former affiliation (University of Tokyo) was published in Angewandte Chemie. In this paper, we created an Ubiquitin-based agonist molecule that promotes dimerization of the HGF receptor MET. MET-binding peptide were genetically introduced into polyubiquitin by a cyclic peptide grafting technique (Lasso Grafting). This research is a collaborative research with Dr. Matsumoto's group at the Cancer Research Institute, Kanazawa University. Dr. Terasaka was in charge of mRNA display and experimental design of protein expression.


https://onlinelibrary.wiley.com/doi/10.1002/anie.202307157

 
 

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